Pandemic Preparedness, Prevention, and Response

DCP-4 Volume 2 cover

About Volume 2

New modeling for DCP4 suggests more than a 20 percent probability in the next decade of another pandemic with mortality comparable to COVID-19. This Volume provides practical guidance for countries to prevent, prepare for, and respond to pandemics. Drawing on COVID-19 lessons, it identifies key priorities to build resilient systems that protect lives and economies through evidence-based national and regional actions.

Early chapters focus on prevention—reducing zoonotic risks, strengthening biosafety measures, improving early detection systems, and rapidly characterizing and containing outbreaks. Other chapters discuss targeted public health measures and broader public health and social measures to curb transmission. Core health system investments receive particular attention, especially oxygen systems, emergency care, and vaccine delivery infrastructure that serve both routine and pandemic needs. Later chapters address medical countermeasures, proposing prearranged financing and decentralized manufacturing to accel­erate deployment and reduce disparities.

Finally, the volume presents a comprehensive framework for pandemic financing that spans the entire pandemic cycle, emphasizing the need for timely, adequate, and effective financial resources. The framework is designed to support policy makers in countries at all income levels and provides a guide to appropriate financing tools for each stage of a pandemic.

Volume 2 Contents

Front Matter

Introduction: Lessons for Pandemic Policy

Chapter 1: Responding to Pandemic Risk: What Countries and Regions can do within the Constraints of Limited Global Cooperation and Solidarity

Chapter 2: Estimated Future Mortality from Pathogens of Epidemic and Pandemic Potential

Chapter 3: One Health: A Comprehensive Approach to Improving Global Health in a Changing World

Chapter 4: Biosafety and Biosecurity

Chapter 5: Early Outbreak Detection and Control, and Prepandemic Preparedness

Chapter 6: Public Health and Social Measures for Respiratory Infections

Chapter 7: Targeted Isolation and Related Measures to Control Epidemic Pathogens

Chapter 8: The Role of School Closures and the Education System in Pandemic Preparedness and Response

Chapter 9: Pandemic Preparedness and Prevention: Vaccination

Chapter 10: Investing in Vaccines to Mitigate Harm from COVID-19 and Future Pandemics

Chapter 11: An “Always On” Approach to Health Care and Public Health Systems: Building Standing Capabilities that can Respond to Shocks and Emergencies

Chapter 12: Priorities for Acute Care Systems during Pandemics: Lessons from COVID-19

Chapter 13: Financing the Pandemic Cycle: Prevention, Preparedness, Response, and Recovery and Reconstruction

Chapter 14: Designing Trigger Mechanisms for Epidemic and Pandemic Financing and Response

Chapter 15: Ethical Issues in Pandemic Prevention, Preparedness, and Response

Back Matter

Online Annexes

Annex: Chapter 2

Annex: Chapter 9

Annex: Chapter 12